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Channel: JAMA Neurology: Motor Neuron Disease Topic Collection
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Clinical Trials of Therapies for Amyotrophic Lateral Sclerosis

This Viewpoint discusses amyotrophic lateral sclerosis as a syndrome rather than a single disease that requires varied diagnostic and therapeutic approaches.

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Heritability of Amyotrophic Lateral Sclerosis

This Viewpoint discusses different techniques for estimating the heritability of amyotrophic lateral sclerosis.

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Diabetes Mellitus, Obesity, and Amyotrophic Lateral Sclerosis

This population-based case-control study investigates the risk of amyotrophic lateral sclerosis associated with diabetes and obesity among Danish individuals.

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Transglutaminase 6 Antibodies in the Serum of Patients With ALS

This case-control study suggests that an amyotrophic lateral sclerosis syndrome might be associated with autoimmunity and gluten sensitivity.

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Biogenesis and Myogenesis in Spinal Muscular Atrophy

This review of oxidative metabolism in biopsy samples finds that an altered regulation of myogenesis and a downregulated mitochondrial biogenesis contribute to pathologic change in the muscle of...

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Effect of Presymptomatic Dietary Intake on Amyotrophic Lateral Sclerosis

This case-control study evaluates the association of premorbid body mass index, dietary intake of fat, and alcohol use with amyotrophic lateral sclerosis.

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Cortical Function and C9orf72 Amyotrophic Lateral Sclerosis

This study investigates whether cortical hyperexcitability forms the pathophysiological basis of c9orf72 familial amyotrophic lateral sclerosis using the threshold-tracking transcranial magnetic...

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Cortical Hyperexcitability in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating disease of the motor nervous system. While most cases are sporadic, approximately 5% to 10% of cases are familial and result from mutation in 1 of...

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Importance of Rare Subtypes in Peripheral Neuropathy

This review article describes rare localizations of peripheral neuropathy, including the appropriate diagnostic evaluation and available treatments.

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Physical Activity and Amyotrophic Lateral Sclerosis Mortality in Women

This cohort study uses data from the Women’s Health Initiative to evaluate whether physical activity is associated with risk of death from amyotrophic lateral sclerosis among postmenopausal women.

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Stem Cell Transplantation in Amyotrophic Lateral Sclerosis

These 2 open-label proof-of-concept studies aim to determine the safety and possible clinical efficacy of autologous mesenchymal stem cell–neurotrophic growth factor cell transplantation in patients...

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Role of APOE in the Occurrence of Frontotemporal Dementia in ALS

This study assesses the influence of the APOE and C9ORF72 genotypes on cognitive impairment in a population-based series of Italian patients with amyotrophic lateral sclerosis.

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Environmental Toxins and Amyotrophic Lateral Sclerosis

This case-control study evaluates the association of exposures to environmental toxins with the odds of developing amyotrophic lateral sclerosis.

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The Role of Environmental Toxins in Amyotrophic Lateral Sclerosis Risk

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that carries a high degree of disability and eventually leads to respiratory failure. The incidence of ALS is estimated to...

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CAMTA1 Gene and Survival in Sporadic Amyotrophic Lateral Sclerosis

This genome-wide association study investigates genetic loci associated with survival in an international population of patients with amytrophic lateral sclerosis.

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Variability in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating fatal paralytic neurodegenerative disorder that is driven by complex and insufficiently understood pathophysiologic mechanisms. In the clinic, ALS...

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